diff --git a/lib/md4.c b/lib/md4.c
index c3934ec79d..1ac6ef1c5b 100644
--- a/lib/md4.c
+++ b/lib/md4.c
@@ -213,8 +213,7 @@ typedef struct md4_ctx MD4_CTX;
  * The check for little-endian architectures that tolerate unaligned memory
  * accesses is an optimization. Nothing will break if it does not work.
  */
-#if defined(__i386__) || defined(__x86_64__) || \
-    defined(__vax__) || defined(__powerpc64__)
+#if defined(__i386__) || defined(__x86_64__) || defined(__vax__)
 #define MD4_SET(n) (*(const uint32_t *)(const void *)&ptr[(n) * 4])
 #define MD4_GET(n) MD4_SET(n)
 #else
diff --git a/lib/md5.c b/lib/md5.c
index 53d93aa564..c2bd176dc9 100644
--- a/lib/md5.c
+++ b/lib/md5.c
@@ -294,8 +294,7 @@ typedef struct md5_ctx my_md5_ctx;
  * The check for little-endian architectures that tolerate unaligned memory
  * accesses is an optimization. Nothing will break if it does not work.
  */
-#if defined(__i386__) || defined(__x86_64__) || \
-    defined(__vax__) || defined(__powerpc64__)
+#if defined(__i386__) || defined(__x86_64__) || defined(__vax__)
 #define MD5_SET(n) (*(const uint32_t *)(const void *)&ptr[(n) * 4])
 #define MD5_GET(n) MD5_SET(n)
 #else