diff --git a/CMakeLists.txt b/CMakeLists.txt
index 9ec7dd433a..a0764b3402 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -904,6 +904,12 @@ if(USE_MSH3)
   if(USE_NGTCP2 OR USE_QUICHE)
     message(FATAL_ERROR "Only one HTTP/3 backend can be selected")
   endif()
+  if(NOT WIN32)
+    if(NOT USE_OPENSSL)
+      message(FATAL_ERROR "msh3/msquic requires OpenSSL fork with QUIC API")
+    endif()
+    openssl_check_quic()
+  endif()
   find_package(MSH3 REQUIRED)
   include_directories(SYSTEM ${MSH3_INCLUDE_DIRS})
   list(APPEND CURL_LIBS ${MSH3_LIBRARIES})