diff --git a/lib/vtls/openssl.c b/lib/vtls/openssl.c
index 924cd1c7e2..88fd0ed634 100644
--- a/lib/vtls/openssl.c
+++ b/lib/vtls/openssl.c
@@ -3903,11 +3903,7 @@ static CURLcode ossl_connect_step2(struct Curl_cfilter *cf,
              error_buffer */
           strcpy(error_buffer, "SSL certificate verification failed");
       }
-#if (OPENSSL_VERSION_NUMBER >= 0x10101000L &&   \
-     !defined(LIBRESSL_VERSION_NUMBER) &&       \
-     !defined(OPENSSL_IS_BORINGSSL) &&          \
-     !defined(OPENSSL_IS_AWSLC))
-
+#if defined(SSL_R_TLSV13_ALERT_CERTIFICATE_REQUIRED)
       /* SSL_R_TLSV13_ALERT_CERTIFICATE_REQUIRED is only available on
          OpenSSL version above v1.1.1, not LibreSSL, BoringSSL, or AWS-LC */
       else if((lib == ERR_LIB_SSL) &&